Lionel Carmant, M.D.

Lionel Carmant is an associate professor in the Department of Pediatrics of the Faculty of Medicine at the Université de Montréal.

CONTACT

CHU Sainte-Justine
3,175 Cote-Ste-Catherine
Montreal, Quebec
Canada, H3T 1C5
Phone: 514- 345-4653
Fax: 514- 345-4787
E-mail: :lionel.carmant@umontreal.ca

SUMMARY OF RESEARCH ACTIVITIES

Laboratory research concentrates on the mechanisms involved in brain damage resulting from epileptic seizures and the means of preventing it. The work relies on both clinical research and basic science using new antiepileptic drugs, surgery, and the study of the neuropsychological impact of seizures on human development. Both in vivo and in vitro studies are done to develop new treatments to control epileptic seizures and seizure-induced brain damage in order to gain understanding of the pathophysiology of this complex process.

Research focuses on, among other things, the role of intracellular calcium stores and their release by metabotropic glutamate receptors. For our in vivo studies, we use video-EEG monitoring of rats exposed to kainic acid. We also use tests that measure neuropsychological function, mainly the Water Maze, and neuropathological assessments of hippocampal lesions.

Presently, we are developing a model for the study of atypical febrile seizures. For our in vitro tests, we use patch-clamp intracellular recordings of neurons, which we combine with simultaneous calcium imaging techniques to correlate neurophysiological changes with fluctuations in intracellular calcium.

STUDIED DISEASE

Epilepsy

SELECTED PUBLICATIONS

Carmant L. Developing a new animal model of temporal lobe epilepsy. Med Sci (Paris). 2007 Nov;23(11):929-33. French.

Prévost J, Lortie A, Nguyen D, Lassonde M, Carmant L. Nonlesional frontal lobe epilepsy (FLE) of childhood: clinical presentation, response to treatment and comorbidity. Epilepsia. 2006 Dec;47(12):2198-201.

Carmant L. Mechanisms that might underlie progression of the epilepsies and how to potentially alter them. Adv Neurol. 2006;97:305-14. Review.

Birca A, Carmant L, Lortie A, Lassonde M. Interaction between the flash evoked SSVEPs and the spontaneous EEG activity in children and adults. Clin Neurophysiol. 2006 Feb;117(2):279-88. Epub 2005 Dec 22.

Seshia SS, Carmant L. Visual-sensitive epilepsies: classification and review. Can J Neurol Sci. 2005 Aug;32(3):298-305. Review.

Vanasse CM, Béland R, Carmant L, Lassonde M. Impact of childhood epilepsy on reading and phonological processing abilities. Epilepsy Behav. 2005 Sep;7(2):288-96.

Birca A, Guy N, Fortier I, Cossette P, Lortie A, Carmant L. Genetic influence on the clinical characteristics and outcome of febrile seizures--a retrospective study. Eur J Paediatr Neurol. 2005;9(5):339-45.

Scantlebury MH, Gibbs SA, Foadjo B, Lema P, Psarropoulou C, Carmant L. Febrile seizures in the predisposed brain: a new model of temporal lobe epilepsy. Ann Neurol. 2005 Jul;58(1):41-9.

Chau V, Karvelas G, Jacob P, Carmant L. Early treatment of Aicardi syndrome with vigabatrin can improve outcome. Neurology. 2004 Nov 9;63(9):1756-7. No abstract available.

USEFUL LINK
CHU Ste-Justine Research Centre

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