Patrick Cossette, M.D., Ph.D.

Dr. Patrick Cossette is an assistant professor in the Department of Medicine at the Université de Montréal.

CONTACT

CHUM Research Centre
Montreal, Quebec
Canada
Email: patrick.cossette@umontreal.ca

SUMMARY OF RESEARCH ACTIVITIES

Dr. Cossette’s laboratory research specializes in epilepsy. His research work is based on genomics and molecular genetics and attempts to identify the genes responsible for the different forms of epilepsy.

STUDIED DISEASES

Epilepsy

Epilepsy

Kinirons P, Verlaan DJ, Dubé MP, Poirier J, Deacon C, Lortie A, Clément JF, Desbiens R, Carmant L, Cieuta-Walti C, Shevell M, Rouleau GA, Cossette P. A novel locus for idiopathic generalized epilepsy in French-Canadian families maps to 10p11. Am J Med Genet A. 2008 Mar 1;146(5):578-84.

Dion MH, Novotny EJ Jr, Carmant L, Cossette P, Nguyen DK. Lamotrigine therapy of epilepsy with Angelman's syndrome. Epilepsia. 2007 Mar;48(3):593-6. Epub 2007 Feb 22.

Nguyen DK, Podubnaia AB, Carmant L, Guilbert F, Cossette P. Generalized epilepsy and classic spike-wave discharges with unilateral thalamic lesions. Arch Neurol. 2006 Sep;63(9):1321-3.

Maljevic S, Krampfl K, Cobilanschi J, Tilgen N, Beyer S, Weber YG, Schlesinger F, Ursu D, Melzer W, Cossette P, Bufler J, Lerche H, Heils A. A mutation in the GABA(A) receptor alpha(1)-subunit is associated with absence epilepsy. Ann Neurol. 2006 Jun;59(6):983-7.

Cossette P, Rouleau GA. Monogenic epilepsies in humans: molecular mechanisms and relevance for the study of intractable epilepsy. Adv Neurol. 2006;97:381-8. Review.

Turnbull J, Lohi H, Kearney JA, Rouleau GA, Delgado-Escueta AV, Meisler MH, Cossette P, Minassian BA. Sacred disease secrets revealed: the genetics of human epilepsy. Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:2491-2500. Review. Corrected and republished in: Hum Mol Genet. 2005 Oct 15;14 Spec No. 2:2491-2500.

Birca A, Guy N, Fortier I, Cossette P, Lortie A, Carmant L. Genetic influence on the clinical characteristics and outcome of febrile seizures--a retrospective study. Eur J Paediatr Neurol. 2005;9(5):339-45. Epub 2005 Jun 23.

Cossette P, Lortie A, Vanasse M, Saint-Hilaire JM, Rouleau GA. Autosomal dominant juvenile myoclonic epilepsy and GABRA1. Adv Neurol. 2005;95:255-63. Review.

Cossette P, Loukas A, Lafrenière RG, Rochefort D, Harvey-Girard E, Ragsdale DS, Dunn RJ, Rouleau GA. Functional characterization of the D188V mutation in neuronal voltage-gated sodium channel causing generalized epilepsy with febrile seizures plus (GEFS). Epilepsy Res. 2003 Feb;53(1-2):107-17.

Cossette P, Liu L, Brisebois K, Dong H, Lortie A, Vanasse M, Saint-Hilaire JM, Carmant L, Verner A, Lu WY, Wang YT, Rouleau GA. Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. Nat Genet. 2002 Jun;31(2):184-9. Epub 2002 May 6.

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