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François Lespérance, M.D.

Dr. François Lesprance is a research associate professor in the Department of Psychiatry of the Faculty of Medicine at the Université de Montréal and the head of the Department of Psychiatry at the Centre hospitalier de l’Université de Montréal.



Centre hospitalier de l’Université de Montréal
1560 Sherbrooke Street East
Montreal, Quebec
Canada H2L 4M1

Phone: (514) 376-3330 extension 3761
Fax: (514) 376-1355
Email :francois.lesperance@umontreal.ca


Dr. Lespérance does research on cardiovascular psychophysiology and the psychosocial factors affecting the cost of health care for coronary patients. Dr. Lespérance is particularly interested in the prognostic impact of depression on cardiovascular disease and the neurobiology of depression applied to cardiovascular disease.


Depression, cardiovascular disease.


van Zyl LT, Lespérance F, Frasure-Smith N, Malinin AI, Atar D, Laliberté MA, Serebruany VL. Platelet and endothelial activity in comorbid major depression and coronary artery disease patients treated with citalopram: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy Trial (CREATE) biomarker sub-study. J Thromb Thrombolysis. 2008 Jan 11; [Epub ahead of print]

Frasure-Smith N, Lespérance F. Depression and anxiety as predictors of 2-year cardiac events in patients with stable coronary artery disease. Arch Gen Psychiatry. 2008 Jan;65(1):62-71.

Frasure-Smith N, Lespérance F. Depression and coronary artery disease. Herz. 2006 Dec;31 Suppl 3:64-8. Review.

Lespérance F, Frasure-Smith N. Depression and heart disease. Cleve Clin J Med. 2007 Feb;74 Suppl 1:S63-6. Review.

Atar D, Malinin A, Pokov A, van Zyl L, Frasure-Smith N, Lesperance F, Serebruany VL. Antiplatelet properties of escitalopram in patients with the metabolic syndrome: a dose-ranging in vitro study. Neuropsychopharmacology. 2007 Nov;32(11):2369-74. Epub 2007 Mar 14.

Duan QL, Dubé MP, Frasure-Smith N, Barhdadi A, Lesperance F, Théroux P, St-Onge J, Rouleau GA, McCaffery JM. Additive effects of obesity and TCF7L2 variants on risk for type 2 diabetes among cardiac patients. Diabetes Care. 2007 Jun;30(6):1621-3. Epub 2007 Mar 10.

Lespérance F, Frasure-Smith N, Koszycki D, Laliberté MA, van Zyl LT, Baker B, Swenson JR, Ghatavi K, Abramson BL, Dorian P, Guertin MC; CREATE Investigators. Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial. JAMA. 2007 Jan 24;297(4):367-79. Erratum in: JAMA. 2007 Jul 4;298(1):40.

Frasure-Smith N, Lespérance F, Irwin MR, Sauvé C, Lespérance J, Théroux P. Depression, C-reactive protein and two-year major adverse cardiac events in men after acute coronary syndromes. Biol Psychiatry. 2007 Aug 15;62(4):302-8. Epub 2007 Jan 8.

Frasure-Smith N, Lespérance F. Coronary heart disease and depression: the next steps. Can J Psychiatry. 2006 Oct;51(12):727-9.


Département de psychiatrie – Université de Montréal,


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