Alexandre Prat, M.D.
Alexandre Prat is Adjunct Professor at the Faculty of Medicine at the Université de Montréal. He directs the Neuroimmunology Laboratory at the CHUM Research Centre.
CHUM Research Centre
SUMMARY OF RESEARCH ACTIVITIES
Part of our research team focuses on the immunological roles of CD4+T helper lymphocytes in MS, the mechanisms of monocytes and lymphocyte migration across the BBB and the physiological regulation of the BBB by glial cells. Other members of the team study the role of novel tight junction molecules of the human BBB and the influence of glial cell factors on junction formation. We believe that a better knowledge of the molecular composition of the BBB will lead to the understanding of diseases such as MS, as well as to the discovery of novel routes for delivery of drugs and chemotherapies for the treatment of neurodegenerative diseases and brain tumors.
Our research focuses on the disease multiple sclerosis and on the general topic of cerebral Immunity.
Cayrol R, Wosik K, Dodelet-Devillers, A, Ifergan I, Kébir H, Haqqani A, Kreymborg K, Becher B, Stanimirovic D and Prat A. ALCAM promotes leukocyte infiltration to the CNS. Nat Immunol. 2008 Feb;9(2):137-45. Epub 2007 Dec 23.