Jean-Claude Lacaille, Ph.D.

Jean-Claude Lacaille est professeur titulaire au Département de physiologie de la Faculté de médecine de l’Université de Montréal.

COORDONNÉES

Université de Montréal
Pavillon Paul-G. Desmarais, Bureau 5113
Montréal, (QC), Canada

Téléphone : 514-343-5794
Email :jean-claude.lacaille@umontreal.ca

RÉSUMÉ DES ACTIVITÉS DE RECHERCHE

PRINCIPALES MALADIES ÉTUDIÉES

PRINCIPALES PUBLICATIONS

Perez, Y., Morin, F. and Lacaille J.-C. A hebbian form of long-term potentiation dependent on mGIuR1a in hippocampal inhibitory interneurons. Proc. Nat. Acad. Sci., 98 :9401-9406, 2001.

Maccaferri, G. and Lacaille, J.-C. Hippocampal interneuron classification – making things as simple as possible, not simpler. TINS, 26,564-571, 2003.

Lapointe, V., Morin, F., Ratté, S., Croce, A., Conquet, F. and Lacaille, J.-C. Synapse-specific mGluR1-dependent long-term potentiation in interneurons regulates hippocampal inhibition. J. Physiol., 555, 125-135, 2004.

Topolnik, L., Congar, P. & Lacaille, J.-C. Differential regulation of mGluR- and AMPAR-mediated dendritic Ca2+ signals by pre- and postsynaptic activity in hippocampal interneurons. Journal of Neuroscience 25, 990-1101, 2005.

Costa-Mattioli, M., Gobert, D., Harding, H., Herdy, B., Azzi, M., Bruno, M., Bidinosti, M., Ben Mamou, C., Marcinkiewicz, E., Yoshida, M., Imataka, H., Cuello, A.C., Seidah, N., Sossin, W., Lacaille, J. C., Ron, D., Nader, K. & Sonenberg, N. Translational control of hippocampal synaptic plasticity and memory by the eIF2α kinase GCN2. Nature 436, 1166-1170, 2005.

Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjević K, Lacaille JC, Nader K, Sonenberg N. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell. 2007 Apr 6;129(1):195-206.

Le Vasseur M, Ran I, Lacaille JC. Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus. Neuroscience. 2008 Jan 2;151(1):28-42. Epub 2007 Oct 11.

LIENS UTILES

Groupe de recherche sue le système nerveux central (GRSNC),

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