Roger Butterworth, Ph.D.

Roger Butterworth is Full Professor in the Faculty of Medicine at the University of Montréal. He directs the Research in Neurological Sciences Unit at the CHUM St-Luc Hospital.

CONTACT

Research in Neurological Sciences Unit
CHUM St-Luc Hospital
1058 St. Denis Street, Montreal, Quebec, H2X 3J4

Phone : 5514-890-8310 ext. 35740
FAX : 514-281-2492
Email :roger.butterworth@umontreal.ca

SUMMARY OF RESEARCH ACTIVITIES

Dr. Butterworth holds a doctoral degree from the University of London, and is interested in the genetic aspects of metabolic encephalopathies (Wernicke-Korsakoff syndrome, hepatic encephalopathy, uremic encephalopathy) as well as the interactions of alcohol and vitamin B1 in the central nervous system. His lab group works to identify the monoaminergic and glutametergic systems in hepatic encephalopathy as well as the amino acid neurotransmitters (GABA, glycine, glutamate, taurine). Dr. Butterworth was President of the International Society of Neurochemistry from 2005-2007, and is currently President of the International Society for Hepatic Encephalopathy and Nitrogen Metabolis.

SELECTED PUBLICATIONS

Ahboucha, S., Pomier-Layrargues, G., Mamer, O. and Butterworth, R.F. Increased brain concentrations of a neuroinhibitory steroid in human hepatic encephalopathy. Ann Neurol. 58(1): 169-70, 2005

Bélanger, M., Desjardins, P., Chatauret. N. and Butterworth, R.F.  Selectively increased expression of the astrocytic/endothelial glucose transporter protein GLUT1 in acute liver failure (p NA). Glia 53(5): 557-562, 2006

Vaquero, J. and Butterworth R.F. The brain glutamate system in liver failure. J Neurochem 98(3): 661-669, 2006

Vaquero, J., Bélanger, M., James, L., Herrero, R., Desjardins, P., Cote, J., Blei, A.T. and Butterworth, R.F. Mild hypothermia attenuates liver injury and improves survival in mice with acetaminophen toxicity. Gastroenterology, 132 (1): 372- 383, 2007

Vaquero, J. and Butterworth, R.F. Mild hypothermia in the treatment of acute liver failure: what are we waiting for?. Nature Clinical Practice Gastroenterology and Hepatology 4(10): 528-529, 2007

Navarro, D., Zwingmann, C. and Butterworth, R.F. Region-selective alterations of glucose oxidation and amino acid synthesis in the thiamine-deficient rat brain: a re-evaluation using (1)H/(13)C NMR spectroscopy. J Neurochem. 2008 Apr 12; [Epub ahead of print]

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